Archive for December, 2013

Posted: December 30, 2013 in Uncategorized

art still exists to give shape to multiple ways of being. – Zweig, via Hans Ulrich Obrist



Transcranial amelioration of inflammation and cell death after brain injury

Theodore L. Roth, Debasis Nayak, Tatjana Atanasijevic, Alan P. Koretsky, Lawrence L. Latour & Dorian B. McGavern
Nature (2013) doi:10.1038/nature12808
Published online 08 December 2013

Traumatic brain injury (TBI) is increasingly appreciated to be highly prevalent and deleterious to neurological function1, 2. At present, no effective treatment options are available, and little is known about the complex cellular response to TBI during its acute phase. To gain insights into TBI pathogenesis, we developed a novel murine closed-skull brain injury model that mirrors some pathological features associated with mild TBI in humans and used long-term intravital microscopy to study the dynamics of the injury response from its inception. Here we demonstrate that acute brain injury induces vascular damage, meningeal cell death, and the generation of reactive oxygen species (ROS) that ultimately breach the glial limitans and promote spread of the injury into the parenchyma. In response, the brain elicits a neuroprotective, purinergic-receptor-dependent inflammatory response characterized by meningeal neutrophil swarming and microglial reconstitution of the damaged glial limitans. We also show that the skull bone is permeable to small-molecular-weight compounds, and use this delivery route to modulate inflammation and therapeutically ameliorate brain injury through transcranial administration of the ROS scavenger, glutathione. Our results shed light on the acute cellular response to TBI and provide a means to locally deliver therapeutic compounds to the site of injury.

via Transcranial amelioration of inflammation and cell death after brain injury : Nature : Nature Publishing Group.

This is a fabulous tool to clarify the complexity of the world; you don’t have to go all over the Internet to understand something; this gets it all together,” said Philippe Destatte, Director of The Destree Institute (Namur, Wallonia) and a sponsor of the Brussels launch of the Global Futures Intelligence System held at Royal Academy of Belgium along with the Club of Rome European Union Chapter and Deloitte.

via Digital global intelligence on the future of the world in the palm of your hand | KurzweilAI.

The art historian David Joselit has described paintings as deep reservoirs of temporal experience—“time batteries”—“exorbitant stockpiles” of experience and information. I would suggest that the same holds true for anything a student might want to study at Harvard University—a star, a sonnet, a chromosome. There are infinite depths of information at any point in the students’ education. They just need to take the time to unlock that wealth.

via Harvard art historian Jennifer Roberts teaches the value of immersive attention | Harvard Magazine Nov-Dec 2013.


This is a great counterpoint to the “Present Shock” book, which reflects on the compression of time that is needed to pass past generation-gleaned knowledge to later generations.
In our fast-paced world, time for reflection will not occur unless it is acknowledged as a priority, and deliberately planned.
Time for reflection is required to learn, and as noted in the essay, required even for perception of deeper meaning. It also requires wise choices of the focus of our deliberation. Reading for the gist of an article, or glancing at a painting can only convey a fraction of its meaning. Patience is an essential skill for development of understanding and meaning – and one that can be honed by practice. 

Reinstalling Eden

Eric Schwitzgebel & R. Scott Bakker

Nature 503, 562 (28 November 2013) doi:10.1038/503562a

Published online 27 November 2013

via Reinstalling Eden : Nature : Nature Publishing Group.

//lw: This is an amazing short story on the virtuality of reality.

THE STONE November 10, 2013, 3:00 pm 454 Comments

Learning How to Die in the Anthropocene


via Learning How to Die in the Anthropocene –

//lw: Can something life-worthy arise from the ashes of our greed?

A Neuroscientist’s Radical Theory of How Networks Become Conscious

BY BRANDON KEIM11.14.136:30 AM

via A Neuroscientist’s Radical Theory of How Networks Become Conscious – Wired Science.

An Interview with Christof Koch.